A recent study indicates that people who discontinue blockbuster GLP-1 drugs like Wegovy and Mounjaro may regain reduced body mass far faster than those who halt traditional diet and exercise programs.
Research printed in a leading medical journal points out that while overweight people frequently drop a large proportion of their total mass while on the medication, the mass returns at an average rate of nearly a kilo each month after stopping.
"Individuals using such drugs need to be informed of the danger of quick rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
Such speed of recovery means a reversion to original mass in about one and a half years.
Comparing Approaches
The research, which examined dozens of studies involving thousands of patients, compared the results of these new drugs with conventional dieting.
Scientists note that individuals who lose weight through lifestyle changes alone typically have a slower weight regain—perhaps 100 grams monthly—after stopping.
Understanding the Quick Regain
Experts propose the mode of action of the drugs is key to understanding the accelerated regain.
These medications mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Long-term administration of the hormone concentrations several times higher than the body's typical production may cause the body to produce less of its own natural hormone, and may also lessen responsiveness to its actions," explained Dr. Adam Collins, a dietetics researcher.
"Stopping of this GLP-1 'fix' means appetite is unsuppressed, making binge eating far more likely."
An Ongoing Condition?
The NHS recommend the injections for people with weight-linked health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, considering the likelihood of weight regain, the treatment should be considered ongoing.
This opinion is reinforced by drug manufacturers, who say that the findings "underscore the persistent nature of obesity," akin to managing diseases like diabetes.
User Testimonies
Users who have discontinued the medication describe a powerful return of hunger.
"I experienced a trigger that goes on and I was suddenly extremely hungry," recalled an individual.
The struggle is exacerbated if patients have not adopted lasting lifestyle or habit changes during treatment.
Significant Interest
Recent estimates indicate that a significant number of people in the UK have used weight-loss jabs in the past year, with demand remaining high.
- Use is more common among women compared to males.
- The middle-aged demographic shows the greatest level of interest.
- Many obtain the medications through private healthcare rather than the NHS.
In conclusion, researchers stress that while GLP-1 drugs are effective tools for shedding pounds, they are not a magic cure and lasting health benefits likely depends on integrated behavioural changes.
